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DNA testing procedure for Vioxx victims

A commonly asked question by those people who took either Vioxx, Celebrex, or Bextra is that how do they know if they have been hurt. Sometimes there are no obvious symptoms but the damage can be enormous. In many cases, your doctor can answer this question and it is best to work with a Vioxx attorney to determine the next step. It is very important to find out if you have been hurt and to what extent to determine if it makes sense to file a lawsuit against Merck of Pfizer.

Now a Seattle-based company, Genelex, may have the solution for this problem using DNA testing. Working with knowledge gleaned from human genome mapping, Genelex has developed consumer-friendly, personal DNA tests, giving physicians, pharmacists and patients the knowledge they need about the way hundreds of prescription, over-the-counter and herbal medicines are individually processed.

More than half of all people have variations detectable by DNA testing that affect the safety and efficacy of these drugs including anti-depressants, anti-inflammatory, pain, and many heart and allergy medications among others. For example, Celebrex is a member of the COX2 inhibitor class of drugs which includes Vioxx and Bextra. The first and most important step in the processing of Celebrex is deficient in five to ten percent of the population. When individuals with this decreased drug processing capacity take Celebrex, the drug levels elevate to abnormal levels in their blood stream. The elevated levels could significantly increase the risk of strokes and heart attack. According to the company, "Patients with the genetically programmed deficiency in Celebrex processing can be identified by simply taking Drug Reaction DNA tests for an enzyme called CYP2C9. These DNA tests have great potential to reduce major medical problems associated with gene-based poor metabolism of prescription drugs."

Pharmaceutical companies currently perform genetic testing during drug development and in clinical trials. With minor exception, however, they have not recommended, nor has the FDA required, that genetic testing be done prior to the drug being prescribed or administered. Drug Reaction DNA Testing kits developed by Genelex Corporation are available via their website without prescription. Consumers receive their results by mail and are urged to share the findings with their physicians and pharmacists. Patients may also obtain a personalized report based on the medicines they are currently taking.

Recommended article: What to do if you took Vioxx but do not have any visible side effects?

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